Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 9/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773903 | 0.98 | CYP2A6 (0.48) | CYP2A6ALDH1A1ACHECYP1A2HPGD | |
| SCHEMBL9696995 | 0.89 | ALDH1A1 (0.40) | CYP2A6ALDH1A1ACHECYP1A2HPGD | |
| SCHEMBL7126850 | 0.86 | ALDH1A1 (0.38) | CYP2A6ALDH1A1ACHECYP1A2HPGD | |
| Iodide SCHEMBL30211080 | 0.80 | ATM (0.54) | ACHEATMMEN1RAB9AKMT2A | |
| Iodide SCHEMBL11862696 | 0.80 | ATM (0.54) | ACHEATMMEN1RAB9AKMT2A | |
| Iodide SCHEMBL8603379 | 0.80 | ATM (0.54) | ACHEATMMEN1RAB9AKMT2A | |
| SCHEMBL28257139 | 0.78 | CYP1A2 (0.47) | CYP2A6ACHECYP1A2ATMMEN1 | |
| Iodide SCHEMBL11862701 | 0.78 | ATM (0.52) | ACHEATMMEN1RAB9AKMT2A | |
| SCHEMBL29464772 | 0.77 | ATM (0.56) | ACHEATMMEN1RAB9AKMT2A | |
| SCHEMBL278568 | 0.77 | ATM (0.56) | ACHEATMMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531008-B2 | Use of at least one cationic cyanin derivative for dyeing the hair, composition containing it, process for treating keratin fibers using the composition, and device therefor | L'OREAL S.A. (FR) | 2009-05-12 | — | — | US | disclosed |
| US-20070143936-A1 | Use of at least one cationic cyanin derivative for dyeing the hair, composition containing it, process for treating keratin fibers using the composition, and device therefor | L'OREAL S.A. (FR) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070143936-A1 | Use of at least one cationic cyanin derivative for dyeing the hair, composition containing it, process for treating keratin fibers using the composition, and device therefor | KRT18, HKDC1, DSC1 | ACHE 1285/4885CYP2A6 1996/4885ALDH1A1 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.