Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 5/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519408 | 0.85 | IDO1 (0.45) | MAPK1LOXL2WNT3A | |
| SCHEMBL17981871 | 0.83 | LOXL2 (0.45) | RAB9AKDM4ELOXL2MEN1KMT2A | |
| SCHEMBL4120500 | 0.82 | CYP11B1 (0.46) | KMOCYP11B1CYP11B2CYP17A1ALDH1A1 | |
| SCHEMBL3904494 | 0.81 | CYP11B1 (0.45) | KMOCYP11B1CYP11B2CYP17A1ALDH1A1 | |
| SCHEMBL28199583 | 0.78 | KMO (0.44) | KMOCYP11B1CYP11B2CYP17A1ALDH1A1 | |
| SCHEMBL896163 | 0.74 | HTT (0.42) | CYP11B1CYP11B2CYP17A1ALDH1A1MAOB | |
| SCHEMBL3907212 | 0.74 | NPC1 (0.46) | CYP11B1CYP11B2RAB9AMAPK1NPC1 | |
| SCHEMBL1437182 | 0.73 | LOXL2 (0.59) | LOXL2 | |
| SCHEMBL2666352 | 0.73 | CCR1 (0.57) | KMOCYP11B1CYP11B2ALDH1A1RAB9A | |
| SCHEMBL3914608 | 0.72 | KMO (0.42) | KMOCYP11B1CYP11B2CYP17A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |