Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 4/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP9 | P55211 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13312397 | 0.78 | GSK3B (0.41) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL8765618 | 0.78 | SRD5A1 (0.41) | AHRTDP2CASP7CASP3CASP9 | |
| SCHEMBL4411843 | 0.77 | AHR (0.61) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL13312445 | 0.76 | BRD4 (0.44) | GSK3BAHRTDP2CASP7CASP3 | |
| SCHEMBL5688415 | 0.73 | GSK3B (0.74) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL30319806 | 0.73 | GSK3B (0.74) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL5332282 | 0.71 | CES1 (0.60) | GSK3BMAOACASP7CASP3CASP6 | |
| SCHEMBL31244367 | 0.71 | CES1 (0.60) | GSK3BMAOACASP7CASP3CASP6 | |
| SCHEMBL1050699 | 0.68 | AHR (0.57) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL13439628 | 0.68 | MAOA (0.56) | MAOACASP7ALDH1A1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954689-A4 | N-SUBSTITUTED-1H-QUINOLINE-2, 4-DIONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RES INST CHEM TECH (KR) | 2009-09-02 | — | — | EP | claimed |
| EP-1954689-A1 | N-SUBSTITUTED-1H-QUINOLINE-2, 4-DIONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-08-13 | — | — | EP | claimed |
| WO-2007032572-A1 | N-SUBSTITUTED-1H-QUINOLINE-2, 4-DIONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2007-03-22 | — | — | WO | claimed |
| EP-1650190-A1 | 3-aryl-3-methyl-quinoline-2,4-diones, preparation method thereof and pharmaceutical composition containing same | Korea Research Institute of Chemical Technology (KR) | 2006-04-26 | — | — | EP | disclosed |