Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 4/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL349481 | 0.92 | DHODH (0.42) | DHODHADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL350126 | 0.92 | OPRM1 (0.39) | ADRA1DADRA1AADRA1BALDH1A1NPC1 | |
| SCHEMBL348690 | 0.68 | AKR1C1 (0.45) | MEN1KMT2AOPRM1 | |
| SCHEMBL507034 | 0.67 | DHODH (0.50) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL31489727 | 0.66 | HTR2A (0.55) | DHODHNPC1RAB9AHRH3 | |
| SCHEMBL23588032 | 0.66 | OPRM1 (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4497428 | 0.65 | CTSK (0.45) | OPRM1 | |
| SCHEMBL10021103 | 0.65 | DHODH (0.58) | DHODHNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14441137 | 0.65 | OPRM1 (0.49) | OPRM1 | |
| SCHEMBL26326631 | 0.65 | DHODH (0.54) | DHODHNPC1RAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |