Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1168220 | 0.87 | IDO1 (0.52) | POLBMAPTUSP2MITFALDH1A1 | |
| SCHEMBL1116563 | 0.83 | IDO1 (0.48) | POLBMAPTUSP2MITFALDH1A1 | |
| SCHEMBL28039374 | 0.80 | DPP4 (0.42) | POLBMAPTALDH1A1LMNAIDO1 | |
| SCHEMBL28887965 | 0.78 | IDO1 (0.44) | POLBMAPTUSP2MITFALDH1A1 | |
| Trimethylammonium SCHEMBL7802297 | 0.78 | ALDH1A1 (0.45) | POLBMAPTUSP2MITFALDH1A1 | |
| SCHEMBL9196333 | 0.77 | SLC6A4 (0.44) | POLBMAPTUSP2MITFALDH1A1 | |
| SCHEMBL6862522 | 0.77 | CYP2A6 (0.44) | POLBMAPTUSP2ALDH1A1LMNA | |
| SCHEMBL15349387 | 0.76 | SMN1; SMN2 (0.49) | POLBMAPTUSP2ALDH1A1IDO1 | |
| SCHEMBL3903024 | 0.76 | PSIP1 (0.43) | POLBMAPTUSP2MITFALDH1A1 | |
| SCHEMBL2492695 | 0.76 | MEN1 (0.45) | POLBMAPTUSP2MITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |