Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11602249 | 0.90 | OPRM1 (0.50) | HTR2AOPRM1GAANPSR1OPRD1 | |
| SCHEMBL3908508 | 0.85 | HTR2A (0.44) | HTR2AOPRM1GAAOPRD1OPRK1 | |
| SCHEMBL27894690 | 0.84 | HTR2A (0.42) | HTR2AOPRM1OPRD1OPRK1 | |
| SCHEMBL23870954 | 0.81 | HTR2A (0.41) | HTR2AOPRM1OPRD1OPRK1 | |
| SCHEMBL25475403 | 0.81 | OPRM1 (0.43) | HTR2AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL23870806 | 0.81 | OPRM1 (0.43) | HTR2AOPRM1OPRD1OPRK1 | |
| SCHEMBL25475388 | 0.81 | HTR2A (0.42) | HTR2AOPRM1OPRD1OPRK1 | |
| SCHEMBL26785458 | 0.81 | HTR2A (0.42) | HTR2AOPRM1OPRD1OPRK1 | |
| SCHEMBL24944239 | 0.79 | OPRM1 (0.49) | HTR2AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL25475293 | 0.79 | HTR2A (0.41) | HTR2AOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |