Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP5C | P53041 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TKT | P29401 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1533810 | 0.89 | PPP5C (0.67) | PPP5CLMNATKTTDP1HSP90AA1 | |
| SCHEMBL2512165 | 0.88 | PPP5C (0.68) | PPP5CLMNATKTTDP1HSP90AA1 | |
| SCHEMBL31477791 | 0.86 | PPP5C (0.70) | PPP5CLMNATKTTDP1HSP90AA1 | |
| SCHEMBL4364375 | 0.84 | PPP5C (0.82) | PPP5CLMNATKTTDP1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL788235 | 0.83 | LMNA (0.67) | PPP5CLMNATKTTDP1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL459651 | 0.82 | LMNA (0.66) | PPP5CLMNATKTTDP1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL15320267 | 0.81 | LMNA (0.65) | PPP5CLMNATKTTDP1HSP90AA1 | |
| SCHEMBL30249786 | 0.80 | LMNA (0.66) | PPP5CLMNATKTTDP1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL5709836 | 0.79 | TDP1 (0.60) | PPP5CLMNATKTTDP1HSP90AA1 | |
| Cocarboxylase SCHEMBL8923435 | 0.76 | LMNA (0.98) | PPP5CLMNATKTTDP1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160289708-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION OF ACETALDEHYDE | JAMIESON ANDREW C (US) | 2016-10-06 | — | — | US | disclosed |
| WO-2009120796-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION OF ACETALDEHYDE | JAMIESON ANDREW C (US) | 2009-10-01 | — | — | WO | disclosed |
| US-20090246841-A1 | Methods and compositions for production of acetaldehyde | JAMIESON ANDREW C | 2009-10-01 | — | — | US | disclosed |