Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3908876 | 1.00 | SYK (0.45) | SYKOPRK1LMNAMEN1MAPT | |
| SCHEMBL311041 | 0.85 | KLK5 (0.36) | MAPTALDH1A1SMN1; SMN2KLK5CASP1 | |
| SCHEMBL6612201 | 0.82 | SYK (0.49) | SYKMAPTKLK5CASP1TRPM8 | |
| SCHEMBL15095154 | 0.82 | SYK (0.58) | SYKKLK5CASP1TRPM8CTSK | |
| SCHEMBL7404713 | 0.82 | SYK (0.53) | SYKMAPTKLK5CASP1TRPM8 | |
| SCHEMBL87318 | 0.82 | SYK (0.58) | SYKKLK5CASP1TRPM8CTSK | |
| SCHEMBL9415864 | 0.81 | CAPN1 (0.42) | CTSK | |
| SCHEMBL7399633 | 0.80 | SYK (0.47) | SYKMAPTKLK5TRPM8PPARA | |
| SCHEMBL27885868 | 0.79 | SYK (0.55) | SYKKLK5TRPM8CTSK | |
| SCHEMBL27658167 | 0.79 | SYK (0.55) | SYKKLK5TRPM8CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660464-B1 | CASPASE INHIBITORS CONTAINING ISOXAZOLINE RING | LG LIFE SCIENCES LTD (KR) | 2015-02-25 | — | — | EP | disclosed |
| US-8481537-B2 | Caspase inhibitors based of pyridazinone scaffold | LG LIFE SCIENCES LTD. (KR) | 2013-07-09 | — | — | US | disclosed |
| US-20090291959-A1 | CASPASE INHIBITORS BASED OF PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2009-11-26 | — | — | US | disclosed |
| US-7557133-B2 | Caspase inhibitors containing isoxazoline ring | LG LIFE SCIENCES LTD. (KR) | 2009-07-07 | — | — | US | disclosed |
| US-20060223848-A1 | Caspase inhibitors containing isoxazoline ring | LG CHEM, LTD. (KR) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223848-A1 | Caspase inhibitors containing isoxazoline ring | CASP1, CASP7, CASP2 | SYK 2106/4885OPRK1 3526/4885LMNA 366/4885 |
| US-20090291959-A1 | CASPASE INHIBITORS BASED OF PYRIDAZINONE SCAFFOLD | CASP1, CASP2, CASP5 | SYK 2321/4885OPRK1 4800/4885LMNA 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.