Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 3/20 | 0.30 |
| ▸ | DRD3 | P35462 | 3/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554142 | 0.74 | HSD11B1 (0.46) | PDE1BDRD2DRD3CHRM1CHRM3 | |
| SCHEMBL4872348 | 0.68 | PDE1B (0.38) | PDE1BDRD2DRD3CHRM1CHRM3 | |
| SCHEMBL5104789 | 0.67 | HSD11B1 (0.44) | — | |
| SCHEMBL5098546 | 0.62 | HSD11B1 (0.51) | — | |
| SCHEMBL17712727 | 0.62 | MEN1 (0.64) | DRD2DRD3CHRM1CHRM3KCNH2 | |
| SCHEMBL22211357 | 0.60 | PDE1B (0.35) | PDE1BDRD2DRD3CHRM1CHRM3 | |
| SCHEMBL5098515 | 0.60 | HSD11B1 (0.49) | — | |
| SCHEMBL5095870 | 0.59 | HSD11B1 (0.48) | — | |
| SCHEMBL18488318 | 0.56 | DRD2 (0.53) | DRD2DRD3CHRM1CHRM3KCNH2 | |
| SCHEMBL1877389 | 0.55 | DRD3 (0.46) | PDE1BDRD2DRD3CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018378-A2 | HETEROCYCLIC INHIBITORS OF 11-B HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2007137066-A2 | HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-11-29 | — | — | WO | claimed |