Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3913434 | 0.90 | KIT (0.37) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2854539 | 0.88 | ACHE (0.45) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2854544 | 0.88 | ACHE (0.45) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL3908051 | 0.86 | KIT (0.38) | ALDH1A1HTTKITMAPTHSD17B10 | |
| SCHEMBL3915607 | 0.86 | KIT (0.38) | ALDH1A1HTTKITMAPTHSD17B10 | |
| SCHEMBL2852692 | 0.77 | CKS1B (0.40) | KCNH2HTTMAPTNPSR1LMNA | |
| SCHEMBL2852695 | 0.77 | CKS1B (0.40) | KCNH2HTTMAPTNPSR1LMNA | |
| SCHEMBL3916386 | 0.75 | KIT (0.37) | HRH1ALDH1A1HTTKITMAPT | |
| SCHEMBL3917775 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1HTTKITMAPTSMN1; SMN2 | |
| SCHEMBL3713595 | 0.71 | GPR119 (0.39) | HRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027108-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | Glaxo Group Limited (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135081-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |