Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910688 | 0.95 | ALDH1A1 (0.36) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL4302090 | 0.84 | BRAF (0.36) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL3141253 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL4298109 | 0.79 | GAA (0.43) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL5396340 | 0.78 | THRA (0.43) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL3911322 | 0.77 | MEN1 (0.42) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL3914958 | 0.77 | GAA (0.53) | ALDH1A1GAAMAPTLMNARAB9A | |
| SCHEMBL4304059 | 0.75 | MAPT (0.35) | ALDH1A1GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL3915777 | 0.73 | THRB (0.44) | — | |
| SCHEMBL4440700 | 0.73 | KDM4E (0.51) | ALDH1A1GAAMAPTSMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024336-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007128492-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2007-11-15 | — | — | WO | disclosed |