Lobaric Acid

Lobaric Acid

SCHEMBL3910434

CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 7/20 1.00
MAPT P10636 3/20 1.00
RECQL P46063 3/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
POLB P06746 2/20 1.00
CYP3A4 P08684 1/20 1.00
MAPK1 P28482 1/20 1.00
HSD17B10 Q99714 1/20 1.00
GPR35 Q9HC97 1/20 1.00
SLCO1B3 Q9NPD5 1/20 1.00
SAE1 Q9UBE0 1/20 1.00
UBA2 Q9UBT2 1/20 1.00
SLCO1B1 Q9Y6L6 1/20 1.00
PTGES O14684 4/20 0.59
KIF20B Q96Q89 2/20 0.59
KDM4E B2RXH2 1/20 0.59
GAA P10253 1/20 0.59
BLM P54132 1/20 0.59
CENPE Q02224 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lobaric Acid SCHEMBL29431924 1.00 PTPN1 (1.00) PTPN1MAPTRECQLMEN1KMT2A
Lobaric Acid SCHEMBL29788372 1.00 PTPN1 (1.00) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL14703230 0.96 PTPN1 (0.93) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL15294483 0.89 PTPN1 (0.80) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL15178484 0.89 PTPN1 (0.80) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL30059040 0.87 PTPN1 (0.77) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL17988184 0.82 MAPT (1.00) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL15294481 0.81 PTPN1 (0.69) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL17975293 0.81 PTPN1 (0.67) PTPN1MAPTRECQLMEN1KMT2A
SCHEMBL17988185 0.76 MAPT (0.77) PTPN1MAPTRECQLMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11434217-B2 Method for synthesis of lobaric acid and analog thereof KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY (KR) 2022-09-06 US disclosed
US-20210246112-A1 METHOD FOR SYNTHESIS OF LOBARIC ACID AND ANALOG THEREOF KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY (KR) 2021-08-12 US disclosed
US-20160220510-A1 ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2016-08-04 US disclosed
US-8846750-B2 Pharmaceutical and food compositions for preventing or treating diabetes or obesity KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE (KR) 2014-09-30 US disclosed
US-20140073614-A1 PHARMACEUTICAL AND FOOD COMPOSITIONS FOR PREVENTING OR TREATING DIABETES OR OBESITY KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE (KR) 2014-03-13 US disclosed
US-20130261174-A1 PHARMACEUTICAL AND FOOD COMPOSITIONS FOR PREVENTING OR TREATING DIABETES OR OBESITY KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE (KR) 2013-10-03 US disclosed
EP-2626070-A2 PHARMACEUTICAL AND FOOD COMPOSITION FOR PREVENTING OR TREATING DIABETES OR OBESITY Korea Ocean Research And Development Insitute (KR) 2013-08-14 EP disclosed
US-20090048332-A1 Natural Novel Antioxidants HEJ RESEARCH INSITUTE (PK) 2009-02-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140073614-A1 PHARMACEUTICAL AND FOOD COMPOSITIONS FOR PREVENTING OR TREATING DIABETES OR OBESITY PTPRC, PPP5C, PPM1B PTPN1 11/4885MAPT 2258/4885RECQL 4485/4885
US-20130261174-A1 PHARMACEUTICAL AND FOOD COMPOSITIONS FOR PREVENTING OR TREATING DIABETES OR OBESITY PTPRC, PPP5C, PPM1B PTPN1 11/4885MAPT 2258/4885RECQL 4485/4885
US-20160220510-A1 ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS AARS1, EPRS1, EEF1G PTPN1 1794/4885MAPT 1595/4885RECQL 2796/4885
US-20210246112-A1 METHOD FOR SYNTHESIS OF LOBARIC ACID AND ANALOG THEREOF PPP6C, PPP4C, PPP3CB PTPN1 129/4885MAPT 948/4885RECQL 4705/4885
US-11434217-B2 Method for synthesis of lobaric acid and analog thereof PPP6C, PPP4C, PPP3CB PTPN1 129/4885MAPT 948/4885RECQL 4705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.