Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1R1 | P14778 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3910310 | 1.00 | IL1R1 (0.39) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3900784 | 0.99 | IL1R1 (0.40) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3900787 | 0.99 | IL1R1 (0.40) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3904916 | 0.98 | IL1R1 (0.39) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3904913 | 0.98 | IL1R1 (0.39) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3900770 | 0.92 | IL1R1 (0.35) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| Bromide SCHEMBL3899754 | 0.87 | L3MBTL1 (0.40) | L3MBTL1KMT2AMEN1ALDH1A1MAPT | |
| Bromide SCHEMBL3904296 | 0.87 | IL1R1 (0.41) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 | |
| Bromide SCHEMBL3897531 | 0.87 | L3MBTL1 (0.40) | L3MBTL1KMT2AMEN1ALDH1A1MAPT | |
| Bromide SCHEMBL3904292 | 0.87 | IL1R1 (0.41) | IL1R1L3MBTL1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517368-B2 | Indolylthiazoliumazo dyes-containing colorants for keratin fibers | WELLA AG (DE) | 2009-04-14 | — | — | US | claimed |
| EP-1716209-B1 | USE OF COMPOSITION CONTAINING INDOLYL THIAZOLIUM AZO DYES FOR DYING KERATIN FIBERS | WELLA AG (DE) | 2009-03-25 | — | — | EP | claimed |
| US-20080271264-A1 | Indolylthiazoliumazo Dyes-Containing Colorants for Keratin Fibers | Wella GmbH (DE) | 2008-11-06 | — | — | US | claimed |
| US-7431741-B2 | Brightening colorant with indolythiazolium dyes | WELLA AG (DE) | 2008-10-07 | — | — | US | claimed |
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | Wella GmbH (DE) | 2007-08-09 | — | — | US | claimed |
| EP-1730239-B1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | WELLA AG (DE) | 2007-05-02 | — | — | EP | claimed |
| US-7517368-B2 | Indolylthiazoliumazo dyes-containing colorants for keratin fibers | WELLA AG (DE) | 2009-04-14 | — | — | US | disclosed |
| US-20080271264-A1 | Indolylthiazoliumazo Dyes-Containing Colorants for Keratin Fibers | Wella GmbH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-7431741-B2 | Brightening colorant with indolythiazolium dyes | WELLA AG (DE) | 2008-10-07 | — | — | US | disclosed |
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | Wella GmbH (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | KRT18, TUBB1, IK | IL1R1 2719/4885L3MBTL1 3924/4885KMT2A 1177/4885 |
| US-20080271264-A1 | Indolylthiazoliumazo Dyes-Containing Colorants for Keratin Fibers | KRT18, IK, TUBA4A | IL1R1 4110/4885L3MBTL1 4607/4885KMT2A 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.