Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3897531 | 1.00 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL3908553 | 0.99 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL3908554 | 0.99 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL3912703 | 0.98 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL3912706 | 0.98 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL3900839 | 0.92 | ALDH1A1 (0.38) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| Bromide SCHEMBL3910310 | 0.87 | IL1R1 (0.39) | L3MBTL1ALDH1A1LMNAMAPTKDM4E | |
| Bromide SCHEMBL3911037 | 0.87 | IL1R1 (0.39) | L3MBTL1ALDH1A1LMNAMAPTKDM4E | |
| Bromide SCHEMBL3901719 | 0.86 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 | |
| Bromide SCHEMBL3901716 | 0.86 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1LMNAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517368-B2 | Indolylthiazoliumazo dyes-containing colorants for keratin fibers | WELLA AG (DE) | 2009-04-14 | — | — | US | claimed |
| EP-1716209-B1 | USE OF COMPOSITION CONTAINING INDOLYL THIAZOLIUM AZO DYES FOR DYING KERATIN FIBERS | WELLA AG (DE) | 2009-03-25 | — | — | EP | claimed |
| US-7431741-B2 | Brightening colorant with indolythiazolium dyes | WELLA AG (DE) | 2008-10-07 | — | — | US | claimed |
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | Wella GmbH (DE) | 2007-08-09 | — | — | US | claimed |
| EP-1730239-B1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | WELLA AG (DE) | 2007-05-02 | — | — | EP | claimed |
| US-7517368-B2 | Indolylthiazoliumazo dyes-containing colorants for keratin fibers | WELLA AG (DE) | 2009-04-14 | — | — | US | disclosed |
| US-20080271264-A1 | Indolylthiazoliumazo Dyes-Containing Colorants for Keratin Fibers | Wella GmbH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-7431741-B2 | Brightening colorant with indolythiazolium dyes | WELLA AG (DE) | 2008-10-07 | — | — | US | disclosed |
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | Wella GmbH (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | KRT18, TUBB1, IK | L3MBTL1 3924/4885ALDH1A1 89/4885LMNA 799/4885 |
| US-20080271264-A1 | Indolylthiazoliumazo Dyes-Containing Colorants for Keratin Fibers | KRT18, IK, TUBA4A | L3MBTL1 4607/4885ALDH1A1 534/4885LMNA 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.