SCHEMBL3911705

SCHEMBL3911705

CO[Si](COC(=O)c1ccncc1)(OC)OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.53
CYP1A2 P05177 2/20 0.53
CYP2C9 P11712 2/20 0.53
CYP2C19 P33261 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
HSD17B10 Q99714 1/20 0.52
L3MBTL1 Q9Y468 3/20 0.50
KDM4E B2RXH2 6/20 0.49
TSHR P16473 2/20 0.49
KMT2A Q03164 2/20 0.49
GLA P06280 1/20 0.49
RAB9A P51151 1/20 0.49
ADRB2 P07550 1/20 0.47
ADRB1 P08588 1/20 0.47
ADRB3 P13945 1/20 0.47
ALDH1A1 P00352 3/20 0.44
NPC1 O15118 2/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
AGTR1 P30556 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3910698 0.84 L3MBTL1 (0.49) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL15070606 0.84 LMNA (0.55) LMNASMN1; SMN2L3MBTL1KDM4ETSHR
SCHEMBL3907608 0.83 L3MBTL1 (0.47) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL3914339 0.80 KMT2A (0.49) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL18905563 0.79 ESR1 (0.40) LMNACYP1A2CYP2C19SMN1; SMN2TSHR
SCHEMBL3910175 0.79 ADRB2 (0.42) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL3910178 0.79 KDM4E (0.43) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
Ethyl Isonicotinate SCHEMBL24935 0.77 CA12 (0.62) LMNACYP1A2CYP2C9CYP2C19HSD17B10
SCHEMBL15953935 0.77 L3MBTL1 (0.59) LMNAHSD17B10L3MBTL1KDM4ETSHR
SCHEMBL14919008 0.76 TSHR (0.55) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090277559-A1 METHOD FOR VULCANIZATION-ADHERING RUBBER COMPOSITION TO ADHERENT OF BRASS OR PLATED WITH BRASS, REINFORCING MEMBER FOR RUBBER ARTICLE, RUBBER-REINFORCING MEMBER COMPOSITE AND PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2009-11-12 US disclosed
EP-1840158-B1 METHOD FOR VULCANIZATION AND ADHESION OF RUBBER COMPOSITION WITH ARTICLE TO BE ADHERED BEING MADE OF BRASS OR PLATED WITH BRASS, REINFORCING MATERIAL FOR RUBBER ARTICLE, RUBBER-REINFORCING MATERIAL COMPOSITE, AND PNEUMATIC TIRE BRIDGESTONE CORP (JP) 2009-02-18 EP disclosed
EP-1840158-A1 METHOD FOR VULCANIZATION AND ADHESION OF RUBBER COMPOSITION WITH ARTICLE TO BE ADHERED BEING MADE OF BRASS OR PLATED WITH BRASS, REINFORCING MATERIAL FOR RUBBER ARTICLE, RUBBER-REINFORCING MATERIAL COMPOSITE, AND PNEUMATIC TIRE Bridgestone Corporation (JP) 2007-10-03 EP disclosed