Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987022 | 0.86 | KCNH2 (0.63) | HRH3KCNH2 | |
| SCHEMBL27829506 | 0.81 | HRH3 (0.51) | HRH3 | |
| SCHEMBL28794109 | 0.77 | HRH3 (0.46) | HRH3 | |
| SCHEMBL14842018 | 0.75 | CA2 (0.40) | — | |
| SCHEMBL3635471 | 0.75 | KCNH2 (0.79) | HRH3KCNH2 | |
| SCHEMBL3923696 | 0.75 | KCNH2 (0.79) | HRH3KCNH2 | |
| Water SCHEMBL14842096 | 0.74 | CA2 (0.40) | — | |
| SCHEMBL27755329 | 0.73 | TSHR (0.40) | — | |
| SCHEMBL1141444 | 0.72 | HRH3 (0.74) | HRH3KCNH2 | |
| SCHEMBL1141441 | 0.72 | HRH3 (0.74) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | claimed |