Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CNR2 | P34972 | 4/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29864596 | 1.00 | ATM (0.60) | ATMKMT2ACYP1A2CNR2CNR1 | |
| SCHEMBL11607263 | 0.88 | CYP1A2 (0.54) | ATMKMT2ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL28639283 | 0.87 | ATM (0.75) | ATMKMT2ACNR1KDM4EALDH1A1 | |
| SCHEMBL7717844 | 0.83 | CYP1A2 (0.59) | CYP1A2CNR2CNR1MAPTCYP2A6 | |
| SCHEMBL18698057 | 0.81 | KMT2A (0.62) | ATMKMT2ACNR1KDM4EALDH1A1 | |
| SCHEMBL7829452 | 0.81 | CYP1A2 (0.56) | ATMKMT2ACYP1A2CNR2CNR1 | |
| SCHEMBL405225 | 0.81 | CYP1A2 (0.56) | KMT2ACYP1A2CNR2CNR1KDM4E | |
| SCHEMBL669648 | 0.81 | CYP1A2 (0.56) | CYP1A2CNR2CNR1KDM4EALDH1A1 | |
| SCHEMBL31347531 | 0.81 | CYP1A2 (0.56) | KMT2ACYP1A2CNR2CNR1KDM4E | |
| SCHEMBL6914442 | 0.79 | CYP1A2 (0.54) | CYP1A2CNR2CNR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1610779-B1 | 3-OXO-1,3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | LILLY CO ELI (US) | 2009-09-09 | — | — | EP | claimed |
| US-20060211755-A1 | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2006-09-21 | — | — | US | claimed |
| EP-1610779-A1 | 3-OXO-1,3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004093872-A1 | 3-OXO-1, 3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | claimed |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-08-09 | — | — | US | disclosed |
| US-9938248-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-04-10 | — | — | US | disclosed |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-03-01 | — | — | US | disclosed |
| US-9834523-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170240521-A1 | PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-24 | — | — | US | disclosed |
| US-20170197925-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2017-07-13 | — | — | US | disclosed |
| US-9656981-B2 | Peripherally-acting cannabinoid receptor agonists for chronic pain | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-05-23 | — | — | US | disclosed |
| US-9611231-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-04-04 | — | — | US | disclosed |
| US-7803826-B2 | Imidazolidine derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1610779-B1 | 3-OXO-1,3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | LILLY CO ELI (US) | 2009-09-09 | — | — | EP | disclosed |
| US-20070249697-A1 | Novel Imidazolidine Derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-10-25 | — | — | US | disclosed |
| US-20070249697-A1 | Novel Imidazolidine Derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1775289-A1 | NOVEL IMIDAZOLIDINE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-04-18 | — | — | EP | disclosed |
| US-20060211755-A1 | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2006-09-21 | — | — | US | disclosed |
| EP-1610779-A1 | 3-OXO-1,3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004093872-A1 | 3-OXO-1, 3-DIHYDRO-INDAZOLE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | ATM 2932/4885KMT2A 2428/4885CYP1A2 402/4885 |
| US-20060211755-A1 | 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors | C5AR2, C3AR1, C5AR1 | ATM 4131/4885KMT2A 2697/4885CYP1A2 1343/4885 |
| US-20170197925-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | ATM 2932/4885KMT2A 2428/4885CYP1A2 402/4885 |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | ATM 2932/4885KMT2A 2428/4885CYP1A2 402/4885 |
| US-20170240521-A1 | PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN | CNR2, CNR1, OPRL1 | ATM 4745/4885KMT2A 4034/4885CYP1A2 2104/4885 |
| US-20070249697-A1 | Novel Imidazolidine Derivatives | CYP3A4, CYP4B1, OPRD1 | ATM 4137/4885KMT2A 3170/4885CYP1A2 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.