Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921754 | 0.83 | NOS2 (0.49) | NOS2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3912150 | 0.81 | NOS2 (0.47) | NOS2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL377863 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL4646792 | 0.81 | KDM1A (0.42) | NOS2KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL3805407 | 0.80 | KDM4E (0.55) | NOS2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL2228142 | 0.80 | IRAK4 (0.43) | NOS2KDM4ELMNANOS3NOS1 | |
| SCHEMBL3913162 | 0.80 | MAPT (0.50) | NOS2MLNRKDM4EALDH1A1MAPT | |
| SCHEMBL3919400 | 0.79 | KDM4E (0.54) | MLNRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4647282 | 0.78 | MAPT (0.49) | NOS2KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL6183532 | 0.74 | SLC6A2 (0.60) | NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029538-A1 | BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007144400-A1 | BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-12-21 | — | — | WO | disclosed |