Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 6/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584506 | 0.81 | AOC3 (0.40) | VCPSLC6A3SLC6A4AOC3NPC1 | |
| SCHEMBL73543 | 0.78 | AOC3 (0.47) | SLC6A3SLC6A4AOC3NPC1RAB9A | |
| SCHEMBL1199883 | 0.76 | AOC3 (0.36) | VCPSLC6A3SLC6A4AOC3NPC1 | |
| SCHEMBL3640169 | 0.75 | AOC3 (0.44) | AOC3NPC1RAB9ALOXL2KDM4E | |
| SCHEMBL10441226 | 0.74 | AOC3 (0.42) | AOC3NPC1RAB9ALOXL2KDM4E | |
| SCHEMBL29688552 | 0.72 | MAOB (0.49) | SLC6A3SLC6A4AOC3MAPT | |
| SCHEMBL1237690 | 0.72 | MAOB (0.49) | SLC6A3SLC6A4AOC3MAPT | |
| SCHEMBL7968720 | 0.70 | HTR2A (0.47) | SLC6A3SLC6A4AOC3NPC1RAB9A | |
| SCHEMBL12534038 | 0.69 | AOC3 (0.41) | SLC6A3SLC6A4AOC3NPC1RAB9A | |
| SCHEMBL6087786 | 0.69 | SMYD3 (0.42) | VCPSLC6A3SLC6A4AOC3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371769-B2 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-05-13 | — | — | US | claimed |
| EP-1828168-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | Solvay Pharmaceuticals B.V. (NL) | 2007-09-05 | — | — | EP | claimed |
| US-20070066634-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SOLVAY PHARMECEUTICALS B.V. (NL) | 2007-03-22 | — | — | US | claimed |
| WO-2006061373-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-06-15 | — | — | WO | claimed |
| US-20060122206-A1 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. | 2006-06-08 | — | — | US | claimed |
| EP-1824486-B1 | BENZDIOXANE PIPERAZINE DERIVATIVES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SOLVAY PHARM BV (NL) | 2009-03-18 | — | — | EP | disclosed |
| US-7371769-B2 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-05-13 | — | — | US | disclosed |
| US-7371769-B2 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-05-13 | — | — | US | disclosed |
| US-7371769-B2 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-05-13 | — | — | US | disclosed |
| CN-101072770-A | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARM BV (NL) | 2007-11-14 | — | — | CN | disclosed |
| CN-101072770-A | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARM BV (NL) | 2007-11-14 | — | — | CN | disclosed |
| EP-1828168-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | Solvay Pharmaceuticals B.V. (NL) | 2007-09-05 | — | — | EP | disclosed |
| EP-1076658-A1 | SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-21 | — | — | EP | disclosed |
| EP-1073651-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055697-A1 | SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |
| WO-1999055695-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |
| US-RE34299-E | Psychological disorders, neuroleptic agents, analgesics | H. LUNDBECK A/S (DK) | 1993-06-29 | — | — | US | disclosed |
| EP-0200322-B1 | HETEROCYCLIC COMPOUNDS | H. LUNDBECK A/S (DK) | 1990-02-28 | — | — | EP | disclosed |
| US-4710500-A | 1-(4'-fluorophenyl)-3,5-substituted indoles useful in the treatment of psychic disorders and pharmaceutical compositions thereof | H. LUNDBECK A/S (DK) | 1987-12-01 | — | — | US | disclosed |
| EP-0200322-A1 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1986-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122206-A1 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SLC6A3, HTR3C, DRD3 | VCP 3647/4885SLC6A3 1/4885SLC6A4 12/4885 |
| US-20070066634-A2 | TETRAHYDROPYRIDIN-4-YL INDOLES WITH A COMBINATION OF AFFINITY FOR DOPAMINE-D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SLC6A3, HTR3C, DRD3 | VCP 3647/4885SLC6A3 1/4885SLC6A4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.