Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916710 | 0.94 | KCNA5 (0.43) | SIGMAR1KCNA5 | |
| SCHEMBL4099571 | 0.87 | NPC1 (0.40) | SIGMAR1ALDH1A1KCNA5LMNA | |
| SCHEMBL3925802 | 0.87 | KCNA5 (0.50) | SIGMAR1ALDH1A1KCNA5 | |
| SCHEMBL3914435 | 0.86 | KCNA5 (0.42) | SIGMAR1KCNA5 | |
| SCHEMBL3917852 | 0.83 | KCNA5 (0.57) | SIGMAR1ALDH1A1MAPTKCNA5LMNA | |
| SCHEMBL3925563 | 0.80 | KCNA5 (0.44) | SIGMAR1ALDH1A1KDM4EMAPTKCNA5 | |
| SCHEMBL3915740 | 0.80 | KCNA5 (0.44) | SIGMAR1ALDH1A1KCNA5LMNA | |
| SCHEMBL3920282 | 0.79 | KCNA5 (0.43) | SIGMAR1CHRM5ALDH1A1KCNA5LMNA | |
| SCHEMBL3916295 | 0.79 | KCNA5 (0.46) | SIGMAR1KCNA5 | |
| SCHEMBL3925872 | 0.79 | KCNA5 (0.43) | SIGMAR1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | claimed |
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |