Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 5/20 | 0.57 |
| ▸ | CA1 | P00915 | 5/20 | 0.57 |
| ▸ | CA2 | P00918 | 5/20 | 0.57 |
| ▸ | CA9 | Q16790 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311956 | 0.85 | LMNA (0.65) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL3915701 | 0.85 | LMNA (0.65) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL15024639 | 0.83 | LMNA (0.80) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL3915318 | 0.82 | LMNA (0.68) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| Etanidazole SCHEMBL4414 | 0.81 | LMNA (1.00) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| Etanidazole SCHEMBL8171462 | 0.81 | LMNA (1.00) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL14023813 | 0.81 | LMNA (0.67) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL5312329 | 0.80 | LMNA (0.70) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL368130 | 0.80 | LMNA (0.78) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| Etanidazole SCHEMBL9473771 | 0.80 | LMNA (0.97) | LMNATHRBCYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2098514-A1 | Preparation of compounds useful for the detection of hypoxia | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-09-09 | — | — | EP | disclosed |
| US-7432295-B2 | Preparation of compounds useful for the detection of hypoxia | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-07 | — | — | US | disclosed |
| US-20060159618-A1 | Preparation of compounds useful for the detection of hypoxia | THE UNIVERSITY OF PENNSYLVANIA | 2006-07-20 | — | — | US | disclosed |
| EP-1202973-A4 | PREPARATION OF COMPOUNDS USEFUL FOR THE DETECTION OF HYPOXIA | UNIV PENNSYLVANIA (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-1202973-A1 | PREPARATION OF COMPOUNDS USEFUL FOR THE DETECTION OF HYPOXIA | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001007414-A1 | PREPARATION OF COMPOUNDS USEFUL FOR THE DETECTION OF HYPOXIA | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060159618-A1 | Preparation of compounds useful for the detection of hypoxia | HIF1AN, HIF1A, HYOU1 | LMNA 1709/4885THRB 2268/4885CYP2C19 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.