Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.53 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1481137 | 0.87 | HRH3 (0.76) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL3916831 | 0.84 | HRH3 (0.76) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL2906006 | 0.84 | HDAC6 (0.68) | HRH3MEN1KMT2AGAA | |
| SCHEMBL2776747 | 0.84 | ALDH1A1 (0.59) | HRH3MEN1KMT2AGAALSS | |
| SCHEMBL3917099 | 0.84 | ALDH1A1 (0.51) | HRH3MEN1KMT2AATMGAA | |
| SCHEMBL3921972 | 0.83 | GAA (0.52) | HRH3MEN1KMT2AATMGAA | |
| SCHEMBL3917811 | 0.82 | POLB (0.49) | HRH3MEN1KMT2AATMGAA | |
| SCHEMBL3918352 | 0.82 | HRH3 (0.50) | HRH3MEN1KMT2AATMGAA | |
| SCHEMBL3917814 | 0.82 | HRH3 (0.49) | HRH3MEN1KMT2AATMGAA | |
| SCHEMBL321890 | 0.82 | HRH3 (0.78) | HRH3MEN1KMT2AATMRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |