Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918352 | 0.90 | HRH3 (0.50) | ALDH1A1SMN1; SMN2HRH3POLBMEN1 | |
| SCHEMBL3917102 | 0.85 | LMNA (0.57) | ALDH1A1SMN1; SMN2HRH3POLBMEN1 | |
| SCHEMBL3916728 | 0.84 | HRH3 (0.71) | HRH3MEN1KMT2AATMGAA | |
| SCHEMBL3915931 | 0.82 | HRH3 (0.44) | ALDH1A1SMN1; SMN2HRH3POLBMEN1 | |
| SCHEMBL3311684 | 0.82 | HRH3 (0.64) | HRH3MEN1KMT2AGAAHDAC6 | |
| SCHEMBL3198447 | 0.82 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL2776747 | 0.80 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2HRH3POLBMEN1 | |
| SCHEMBL2906006 | 0.80 | HDAC6 (0.68) | HRH3MEN1KMT2AGAAHDAC6 | |
| SCHEMBL27282763 | 0.80 | L3MBTL1 (0.74) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL188521 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HRH3POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |