Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5006650 | 0.86 | MCHR1 (0.43) | ALDH1A1KDM4ERAB9AMCHR1KCNH2 | |
| SCHEMBL3917777 | 0.85 | MCHR1 (0.44) | ALDH1A1KDM4EHTTMAPTALOX15 | |
| Hydrochloric Acid SCHEMBL4283833 | 0.85 | MCHR1 (0.42) | ALDH1A1KDM4ERAB9AMCHR1KCNH2 | |
| Hydrochloric Acid SCHEMBL5007613 | 0.85 | MCHR1 (0.43) | ALDH1A1KDM4EHTTMAPTALOX15 | |
| SCHEMBL3927696 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL10049565 | 0.81 | ALOX5 (0.47) | ALDH1A1KDM4EHTTLMNAPDE1A | |
| SCHEMBL5007595 | 0.78 | SPHK2 (0.46) | ALDH1A1KDM4ELMNAKCNH2 | |
| SCHEMBL5004141 | 0.78 | SPHK2 (0.46) | ALDH1A1KDM4ELMNAKCNH2 | |
| SCHEMBL5004139 | 0.77 | SPHK2 (0.43) | ALDH1A1KDM4EKCNH2 | |
| SCHEMBL10049569 | 0.77 | CTSL (0.44) | MAPTALOX15TDP1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188089-B2 | Tylophorine analogs as antitumor agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| EP-1968975-A4 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20080300254-A1 | Tylophorine Analogs as Antitumor Agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| EP-1968975-A2 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | The University of North Carolina at Chapel Hill (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007081540-A2 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300254-A1 | Tylophorine Analogs as Antitumor Agents | RPL30, RPL18A, RPP30 | ALDH1A1 2860/4885KDM4E 3843/4885HTT 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.