Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NCEH1 | Q6PIU2 | 10/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912820 | 0.84 | NCEH1 (0.47) | CYP1A2CYP2C19NCEH1LMNASMN1; SMN2 | |
| SCHEMBL2113122 | 0.82 | CYP1A2 (0.42) | CYP1A2CYP2C19NCEH1LMNASMN1; SMN2 | |
| SCHEMBL1898777 | 0.78 | ALDH1A1 (0.44) | CYP1A2CYP2C19NPC1RAB9ASLC22A12 | |
| SCHEMBL9257525 | 0.77 | LDHA (0.49) | NCEH1LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL7197218 | 0.77 | NCEH1 (0.46) | CYP1A2CYP2C19NCEH1LMNASMN1; SMN2 | |
| SCHEMBL11863351 | 0.76 | NCEH1 (0.65) | CYP1A2CYP2C19NCEH1LMNASMN1; SMN2 | |
| SCHEMBL881195 | 0.75 | MAPT (0.58) | CYP1A2LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1853993 | 0.75 | KDM4E (0.44) | CYP1A2CYP2C19LMNASMN1; SMN2NPC1 | |
| SCHEMBL878536 | 0.74 | ALDH1A1 (0.61) | RAB9APOLBHPGDTDP1L3MBTL1 | |
| SCHEMBL10773502 | 0.73 | TSHR (0.50) | NCEH1LMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858509-A4 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1858509-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094003-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |