Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690328 | 0.84 | LMNA (0.80) | LMNAALDH1A1SIGMAR1HRH3POLB | |
| SCHEMBL3320391 | 0.82 | HRH3 (0.44) | LMNAALDH1A1SIGMAR1HRH3POLB | |
| SCHEMBL7223925 | 0.82 | LMNA (0.61) | LMNAALDH1A1SIGMAR1HRH3POLB | |
| SCHEMBL7658856 | 0.81 | SIGMAR1 (0.69) | LMNAALDH1A1SIGMAR1POLB | |
| SCHEMBL1018073 | 0.79 | MAPT (0.61) | LMNAALDH1A1POLBTDP1 | |
| SCHEMBL14617574 | 0.78 | LMNA (0.56) | LMNAALDH1A1SIGMAR1HRH3POLB | |
| SCHEMBL5625337 | 0.77 | SIGMAR1 (0.75) | LMNAALDH1A1SIGMAR1POLB | |
| SCHEMBL3153045 | 0.77 | ALDH1A1 (0.88) | LMNAALDH1A1HRH3POLBTDP1 | |
| SCHEMBL54966 | 0.77 | ALDH1A1 (0.96) | LMNAALDH1A1HRH3POLBHRH4 | |
| SCHEMBL19847092 | 0.76 | GPR183 (0.42) | LMNAALDH1A1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014060113-A1 | NOVEL KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2014-04-24 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |