Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919507 | 0.92 | HTR6 (0.48) | HTR6ADRB1CYP2C9HDAC6NPC1 | |
| Hydrochloric Acid SCHEMBL5276815 | 0.91 | HTR6 (0.47) | HTR6ADRB1CYP2C9HDAC6NPC1 | |
| SCHEMBL4137576 | 0.87 | HTR6 (0.60) | HTR6FAAHMAPTPOLB | |
| SCHEMBL475619 | 0.84 | ADRB1 (0.46) | HTR6ADRB1ABCB1GUSBMAPT | |
| Hydrochloric Acid SCHEMBL1748218 | 0.83 | ADRB1 (0.45) | HTR6ADRB1ABCB1GUSBMEN1 | |
| SCHEMBL5272631 | 0.81 | HTR6 (0.46) | HTR6ADRB1CYP2C9MAPTPOLB | |
| SCHEMBL475613 | 0.79 | ADRB1 (0.48) | HTR6ADRB1CYP2C9HDAC6ABCB1 | |
| SCHEMBL5279597 | 0.77 | SMN1; SMN2 (0.47) | HTR6CYP2C9HDAC6NPC1RAB9A | |
| SCHEMBL475569 | 0.77 | HDAC4 (0.47) | HTR6MAPTGAAHTT | |
| Hydrochloric Acid SCHEMBL1748931 | 0.76 | HDAC4 (0.46) | HTR6MAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | claimed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | claimed |