Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.60 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272631 | 0.88 | HTR6 (0.46) | HTR6AOC3CETPPOLBMAPT | |
| SCHEMBL3920646 | 0.87 | HTR6 (0.50) | HTR6FAAHPOLBMAPT | |
| SCHEMBL3919507 | 0.85 | HTR6 (0.48) | HTR6AOC3CETPPOLBMAPT | |
| Hydrochloric Acid SCHEMBL5276815 | 0.84 | HTR6 (0.47) | HTR6AOC3CETPPOLBMAPT | |
| SCHEMBL5277473 | 0.82 | HTR6 (0.58) | HTR6MAPTNPSR1SCDALDH1A1 | |
| SCHEMBL475569 | 0.81 | HDAC4 (0.47) | HTR6AOC3MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL1748931 | 0.80 | HDAC4 (0.46) | HTR6AOC3MAPTALDH1A1 | |
| SCHEMBL1748204 | 0.79 | HTR6 (0.50) | HTR6AOC3MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL1748368 | 0.78 | HTR6 (0.49) | HTR6AOC3MAPTALDH1A1 | |
| SCHEMBL5275083 | 0.77 | HDAC3 (0.48) | HTR6RXFP1POLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | claimed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | claimed |
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | claimed |