Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270855 | 0.91 | — | — | |
| Ethylene SCHEMBL29024220 | 0.85 | SLC22A6 (0.42) | SLC22A6 | |
| SCHEMBL9574450 | 0.75 | — | — | |
| SCHEMBL7758306 | 0.75 | TSHR (0.39) | GRIA1CA2 | |
| SCHEMBL7704582 | 0.75 | TSHR (0.39) | GRIA1CA2 | |
| SCHEMBL28243588 | 0.73 | — | — | |
| SCHEMBL549356 | 0.73 | — | — | |
| SCHEMBL11422116 | 0.73 | LMNA (0.36) | CA2 | |
| SCHEMBL20898290 | 0.73 | — | — | |
| SCHEMBL14101777 | 0.72 | SLC22A6 (0.37) | SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8100961-B2 | Elastin stabilization of connective tissue | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2313146-A2 | DEVICES FOR THE TREATMENT OF VASCULAR ANEURYSM | Vatrix Medical, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |
| US-7875587-B2 | such as type 2 diabetes, obesity, insulin resistance; stimules insulin release; dipeptidyl peptidase-IV resistant gastric inhibitory peptide (GIP) analog | UUTECH LIMITED (GB) | 2011-01-25 | — | — | US | disclosed |
| US-20100016833-A1 | Devices for the Treatment of Vascular Aneurysm | NECTERO MEDICAL, INC. | 2010-01-21 | — | — | US | disclosed |