Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448079 | 0.84 | MAOB (0.57) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL11643569 | 0.82 | MAPT (0.64) | SGMS2MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL30257271 | 0.82 | SGMS2 (0.52) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL15602827 | 0.82 | SGMS2 (0.52) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL4452726 | 0.82 | NPC1 (0.52) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL25079152 | 0.82 | SGMS2 (0.52) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL2657882 | 0.81 | SGMS2 (0.51) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL13192152 | 0.79 | ATM (0.52) | SGMS2MAOBMAPK1L3MBTL1XDH | |
| SCHEMBL6356278 | 0.79 | MAPT (0.60) | SGMS2MAOBMAPTMAPK1TDP1 | |
| SCHEMBL8874712 | 0.79 | SGMS2 (0.52) | SGMS2MAOBMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038254-A2 | BICYCLIC COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | Kinex Pharmaceuticals, LLC (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008002674-A2 | BICYCLIC COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2008-01-03 | — | — | WO | disclosed |