Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | TP53 | P04637 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135908 | 0.90 | MAPT (0.69) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16136046 | 0.88 | KDM4E (0.74) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16135907 | 0.86 | KDM4E (0.74) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL3920705 | 0.86 | TSPO (0.54) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16135901 | 0.82 | KDM4E (0.68) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16136098 | 0.81 | KDM4E (0.62) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16136161 | 0.79 | KDM4E (0.69) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL20022622 | 0.79 | KDM4E (0.61) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16311057 | 0.78 | KDM4E (0.77) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL16135893 | 0.78 | KDM4E (0.67) | MAPTTP53KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569567-B2 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use | SANOFI-AVENTIS (FR) | 2009-08-04 | — | — | US | claimed |
| US-20080249098-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide Derivatives, Their Preparation and Therapeutic Use | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249098-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide Derivatives, Their Preparation and Therapeutic Use | HTR3C, TPH1, IDO1 | MAPT 3189/4885TP53 1779/4885KDM4E 2744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.