Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KMO | O15229 | 2/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19194720 | 0.83 | KMT2A (0.44) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL5214284 | 0.79 | KMT2A (0.41) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL3922871 | 0.79 | KDM4E (0.59) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL30912307 | 0.78 | KMO (0.70) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL8613401 | 0.76 | KMO (0.68) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL17595006 | 0.75 | CYP1A2 (0.50) | KDM4EKMT2ASMN1; SMN2ALOX15 | |
| SCHEMBL21199915 | 0.74 | RBP4 (0.41) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL27893460 | 0.74 | KMO (0.65) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL778084 | 0.73 | CYP11B2 (0.46) | HIF1AKDM4ETDP1GLAHTT | |
| SCHEMBL17323525 | 0.73 | KMO (0.50) | HIF1AKDM4ETDP1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191451-B1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP) | 2019-06-05 | — | — | EP | claimed |
| US-20170217889-A1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION (JP) | 2017-08-03 | — | — | US | claimed |
| EP-3191451-A1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | Okinawa Institute of Science and Technology School Corporation (JP) | 2017-07-19 | — | — | EP | claimed |
| WO-2016038890-A1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION (JP) | 2016-03-17 | — | — | WO | claimed |
| EP-1420019-B1 | Substituted pyridino pentaazamacrocyle ligands | MONSANTO CO (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1420022-B1 | Use of substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity | MONSANTO CO (US) | 2007-07-04 | — | — | EP | disclosed |
| EP-1212323-B1 | SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY | MONSANTO CO (US) | 2004-06-09 | — | — | EP | disclosed |
| EP-1420022-A1 | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity | MONSANTO COMPANY (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-1420019-A1 | Substituted pyridino pentaazamacrocyle ligands having superoxide dismutase activity | MONSANTO COMPANY (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2001019823-A9 | SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY | MONSANTO CO (US) | 2002-09-26 | — | — | WO | disclosed |
| EP-1212323-A2 | SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY | MONSANTO COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| US-6214817-B1 | NITROGEN MACROCYCLE COMPLEXES WITH MANGANESE AND IRON | MONSANTO COMPANY | 2001-04-10 | — | — | US | disclosed |
| WO-2001019823-A2 | SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY | MONSANTO COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217889-A1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | PDK2, PKD1, PDHA2 | HIF1A 253/4885KDM4E 750/4885TDP1 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.