Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9746 | 0.84 | SLC6A4 (0.87) | SLC6A4SLC6A2KMT2A | |
| Oxalic Acid SCHEMBL3529 | 0.82 | SLC6A4 (0.46) | SLC6A4KDM4EALDH1A1SMN1; SMN2NPSR1 | |
| Oxalic Acid SCHEMBL2740 | 0.79 | CACNA2D1 (0.67) | SLC6A4SLC6A2KMT2ACACNA2D1 | |
| Oxalic Acid SCHEMBL3312526 | 0.79 | CACNA2D1 (0.67) | SLC6A4SLC6A2KMT2ACACNA2D1 | |
| Oxalic Acid SCHEMBL1535363 | 0.79 | CACNA2D1 (0.67) | SLC6A4SLC6A2KMT2ACACNA2D1 | |
| Oxalic Acid SCHEMBL1555711 | 0.79 | ALDH1A1 (0.38) | SLC6A4SLC6A2KDM4EALDH1A1UTS2R | |
| Oxalic Acid SCHEMBL3900 | 0.78 | CACNA2D1 (0.48) | SLC6A4SLC6A2KDM4EALDH1A1UTS2R | |
| Oxalic Acid SCHEMBL3562 | 0.78 | SLC6A2 (0.63) | SLC6A4SLC6A2KDM4EALDH1A1UTS2R | |
| SCHEMBL9995405 | 0.78 | SLC6A4 (0.67) | SLC6A4SLC6A2UTS2RHTR1BCACNA2D1 | |
| SCHEMBL3924 | 0.78 | SLC6A4 (0.56) | SLC6A4SLC6A2KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |