Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13779379 | 0.77 | NPC1 (0.68) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL14394393 | 0.73 | NPC1 (0.69) | KMT2AALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL17712427 | 0.72 | KMT2A (0.71) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL17318526 | 0.69 | POLB (0.63) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL29848069 | 0.67 | MAPT (1.00) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL1436180 | 0.67 | MAPT (0.68) | KMT2AALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL4461489 | 0.66 | L3MBTL1 (0.57) | KMT2AALDH1A1MAPTMEN1NPC1 | |
| Coumarin SCHEMBL28584180 | 0.66 | TDP1 (0.71) | KMT2AALDH1A1MAPTMEN1POLB | |
| SCHEMBL1929165 | 0.65 | NPC1 (0.85) | KMT2AALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL23011772 | 0.64 | KCNK3 (0.82) | KMT2AMAPTMEN1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006577-A2 | COMPOSITIONS AND METHODS FOR INHIBITING EZH2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-01-08 | — | — | WO | disclosed |