Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3911272 | 0.85 | POLB (0.50) | FAAHKITPOLBPKMATM | |
| SCHEMBL2359227 | 0.82 | FAAH (0.49) | FAAHKITPOLBPKMATM | |
| SCHEMBL3910612 | 0.81 | MGLL (0.58) | ALDH1A1SMN1; SMN2L3MBTL1MGLL | |
| SCHEMBL377536 | 0.80 | VEGFA (0.53) | FAAHALDH1A1HTTSMN1; SMN2HRH3 | |
| SCHEMBL14586757 | 0.78 | HRH3 (0.71) | FAAHPOLBATMALDH1A1HRH3 | |
| SCHEMBL4054843 | 0.76 | KDM4E (0.56) | FAAHPOLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6425987 | 0.75 | ALDH1A1 (0.48) | FAAHATMALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3910347 | 0.73 | HRH1 (0.48) | KITPOLBHRH3 | |
| SCHEMBL3402093 | 0.73 | ALDH1A1 (0.48) | FAAHALDH1A1HTTL3MBTL1MGLL | |
| SCHEMBL22815125 | 0.73 | NPC1 (0.52) | FAAHPOLBATMALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041093-A1 | PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES | Glaxo Group Limited (GB) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008000729-A1 | PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | WO | disclosed |