Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399585 | 0.82 | MAPT (0.52) | ALDH1A1MAPTLMNAKMT2APOLB | |
| SCHEMBL22236053 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL22348729 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL14858678 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL5765504 | 0.77 | SIGMAR1 (0.52) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL3540865 | 0.77 | PARP1 (0.43) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL22348578 | 0.76 | TDP1 (0.47) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL1277890 | 0.76 | MAPT (0.77) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL213412 | 0.75 | LMNA (0.45) | ALDH1A1MAPTLMNATDP1CYP3A4 | |
| SCHEMBL2911533 | 0.74 | MAPT (0.68) | ALDH1A1MAPTLMNATDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035417-A1 | BENZIMIDAZOLES AND THEIR USE FOR THE TREATEMNT OF DIABETES | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007141517-A1 | BENZIMIDAZOLES AND THEIR USE FOR THE TREATEMNT OF DIABETES | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |