Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972329 | 0.90 | MAPT (0.59) | MAPTALDH1A1GPR3GRIN1GRIN2A | |
| SCHEMBL1770370 | 0.83 | TP53 (0.50) | ALDH1A1SMN1; SMN2LMNATP53CYP3A4 | |
| SCHEMBL9047357 | 0.81 | CETP (0.47) | MAPTALDH1A1GPR3GRIN1GRIN2A | |
| SCHEMBL4141130 | 0.81 | MAOB (0.41) | ALDH1A1SMN1; SMN2TP53CYP3A4TSHR | |
| SCHEMBL3250233 | 0.81 | L3MBTL1 (0.54) | ALDH1A1KMT2ALMNAKDM4EL3MBTL1 | |
| SCHEMBL24305918 | 0.81 | MAPK1 (0.55) | MAPTALDH1A1GPR3GRIN1GRIN2A | |
| SCHEMBL9458046 | 0.81 | GPR3 (0.49) | MAPTALDH1A1GPR3GRIN1GRIN2A | |
| SCHEMBL2494479 | 0.81 | MAOB (0.53) | MAPTALDH1A1GPR3GRIN1GRIN2A | |
| SCHEMBL4573178 | 0.81 | CETP (0.44) | MAPTALDH1A1GPR3GRIN1GRIN2B | |
| SCHEMBL1471132 | 0.81 | MAOB (0.55) | MAPTALDH1A1GPR3GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009005460-A1 | SMALL MOLECULE INHIBITORS OF NAVL.7 SODIUM CHANNELS FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |