Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 2/20 | 0.35 |
| ▸ | MMP7 | P09237 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16129346 | 0.76 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1LMNAHTTTSHR | |
| SCHEMBL18065552 | 0.72 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1HTTTSHRMMP2 | |
| SCHEMBL16129195 | 0.70 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1LMNAHTTTSHR | |
| SCHEMBL16635481 | 0.67 | TRPA1 (0.53) | ALDH1A1L3MBTL1LMNAHTTMMP1 | |
| SCHEMBL16635482 | 0.67 | TRPA1 (0.53) | ALDH1A1L3MBTL1LMNAHTTMMP1 | |
| SCHEMBL15577918 | 0.65 | PLCG1 (0.46) | ALDH1A1L3MBTL1LMNAMMP2MMP1 | |
| SCHEMBL3924062 | 0.65 | HCRTR1 (0.47) | LMNAHTTMMP2MMP1MMP3 | |
| SCHEMBL18065474 | 0.64 | TSHR (0.54) | ALDH1A1L3MBTL1HTTTSHRPOLB | |
| SCHEMBL3919293 | 0.64 | TSHR (0.47) | ALDH1A1LMNAHTTTSHRPOLB | |
| SCHEMBL27976150 | 0.63 | HCRTR1 (0.50) | ALDH1A1LMNAHTTMMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |