Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 8/20 | 0.43 |
| ▸ | CASP7 | P55210 | 7/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925016 | 0.84 | HCRTR1 (0.49) | HCRTR1HCRTR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL3913958 | 0.76 | HCRTR1 (0.43) | HCRTR1HCRTR2LMNAHTTGHSR | |
| SCHEMBL27976149 | 0.75 | HCRTR1 (0.50) | HCRTR1HCRTR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL27976150 | 0.75 | HCRTR1 (0.50) | HCRTR1HCRTR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL18065225 | 0.73 | PSEN1 (0.66) | HCRTR1HCRTR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL18065224 | 0.73 | PSEN1 (0.66) | HCRTR1HCRTR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL12170345 | 0.72 | PSEN1 (0.68) | HCRTR1HCRTR2CASP3CASP7LMNA | |
| SCHEMBL3115162 | 0.72 | HCRTR1 (0.62) | HCRTR1HCRTR2CASP3SMN1; SMN2GHSR | |
| SCHEMBL15256571 | 0.72 | CASP3 (0.64) | KCNH2HRH3CASP3CASP7CASP9 | |
| SCHEMBL15800500 | 0.72 | CASP3 (0.64) | KCNH2HRH3CASP3CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |