Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.70 |
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | F2R | P25116 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820503 | 0.86 | CYP1A2 (0.68) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL4977900 | 0.85 | MEN1 (0.62) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL1408451 | 0.81 | MEN1 (0.62) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL10005082 | 0.81 | MAPT (0.74) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL29502906 | 0.81 | MAPT (0.74) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL1449042 | 0.81 | KMT2A (0.55) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL3089202 | 0.79 | MAPT (0.62) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL7283173 | 0.78 | MAPT (0.69) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL100511 | 0.78 | RAB9A (0.56) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL27688485 | 0.78 | MAPT (0.56) | KMT2AMEN1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035386-A1 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149031-A1 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |