Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.58 |
| ▸ | MEN1 | O00255 | 11/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10005082 | 0.85 | MAPT (0.74) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL29502906 | 0.85 | MAPT (0.74) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL1454748 | 0.85 | MAPT (0.63) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL16430329 | 0.85 | MAPT (0.62) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL5897734 | 0.83 | MAPT (0.60) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL374408 | 0.82 | RAB9A (0.65) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL27526687 | 0.82 | MAPT (0.57) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL28787844 | 0.81 | MAPT (0.67) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL3817483 | 0.80 | MEN1 (0.71) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL31650343 | 0.80 | MAPT (0.78) | MAPTLMNANPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234355-A1 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| CN-101506171-A | Isoquinoline derivatives as inhibitors of cytokine mediated diseases and uses thereof | ASTRAZENECA AB (SE) | 2009-08-12 | — | — | CN | disclosed |
| US-20080207596-A1 | Novel compounds 329 | MARTIN BARRIE | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207596-A1 | Novel compounds 329 | CCL11, IL2, IL1B | MAPT 2253/4885LMNA 4014/4885NPC1 1257/4885 |
| US-20100234355-A1 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES | IL2, IFNG, IL1B | MAPT 1124/4885LMNA 3775/4885NPC1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.