Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931415 | 0.90 | REN (0.42) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3928888 | 0.89 | ALOX15 (0.41) | RENSLC6A2SLC6A4SLC6A3PDE4B | |
| SCHEMBL3924961 | 0.88 | REN (0.46) | RENSLC6A2SLC6A4SLC6A3PDE4B | |
| SCHEMBL3933691 | 0.88 | REN (0.44) | RENSLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL3941259 | 0.83 | PDE4B (0.38) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3930491 | 0.83 | TACR1 (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1TACR1 | |
| SCHEMBL3930518 | 0.82 | TACR1 (0.36) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3929051 | 0.82 | TACR1 (0.40) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3928360 | 0.81 | TACR1 (0.39) | SLC6A2SLC6A4SLC6A3ALDH1A1TACR1 | |
| SCHEMBL3938205 | 0.80 | REN (0.39) | RENPARP1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044054-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. Hoffmann-Roche AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008000692-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |