Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931492 | 0.89 | REN (0.41) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3928975 | 0.88 | REN (0.44) | RENSLC6A2SLC6A4SLC6A3PDE4B | |
| SCHEMBL3929666 | 0.88 | REN (0.40) | RENSLC6A2SLC6A4SLC6A3PDE4B | |
| SCHEMBL3939671 | 0.87 | REN (0.45) | RENSLC6A2SLC6A4SLC6A3PDE4B | |
| SCHEMBL3939710 | 0.84 | SLC6A2 (0.40) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3939023 | 0.82 | SLC6A2 (0.37) | RENSLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3939276 | 0.81 | SLC6A2 (0.39) | RENSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3927956 | 0.80 | SLC6A4 (0.39) | RENSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL3937186 | 0.80 | SLC6A2 (0.39) | RENSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3925624 | 0.80 | REN (0.40) | RENSLC6A2SLC6A4SLC6A3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044054-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. Hoffmann-Roche AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008000692-A2 | PYRIMIDINE AND QUINAZOLINE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |