Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4114909 | 0.92 | KCNA5 (0.53) | KCNA5POLBOPRM1OPRL1KCNH2 | |
| SCHEMBL3918255 | 0.89 | KCNA5 (0.51) | KCNA5POLBOPRM1OPRL1KCNH2 | |
| SCHEMBL3927033 | 0.86 | KCNA5 (0.54) | KCNA5CNR1CNR2POLBKCNH2 | |
| SCHEMBL3915654 | 0.86 | KCNA5 (0.48) | KCNA5CNR1CNR2POLBOPRM1 | |
| SCHEMBL3916079 | 0.86 | KCNA5 (0.48) | KCNA5POLBKCNH2ALDH1A1MEN1 | |
| SCHEMBL3916689 | 0.85 | SIGMAR1 (0.43) | KCNA5POLBOPRM1KCNH2ALDH1A1 | |
| SCHEMBL3918962 | 0.80 | KCNA5 (0.45) | KCNA5KCNH2MMP1MMP9MMP13 | |
| SCHEMBL3920593 | 0.79 | KEAP1 (0.44) | KCNA5POLBALDH1A1PKMKMT2A | |
| SCHEMBL3914439 | 0.79 | CA12 (0.43) | KCNA5KCNH2MMP1MMP9MMP13 | |
| SCHEMBL3919007 | 0.79 | KCNA5 (0.49) | KCNA5KCNH2ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |