⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518987 | 0.69 | ALDH1A1 (0.30) | — | |
| SCHEMBL27693760 | 0.67 | TRPA1 (0.39) | — | |
| Ammonia Solution, Strong SCHEMBL28016359 | 0.65 | TRPA1 (0.38) | — | |
| SCHEMBL8371992 | 0.65 | — | — | |
| SCHEMBL6207702 | 0.64 | — | — | |
| SCHEMBL1913184 | 0.64 | — | — | |
| SCHEMBL9940454 | 0.64 | — | — | |
| SCHEMBL6208056 | 0.63 | TRPA1 (0.58) | — | |
| SCHEMBL31408049 | 0.62 | MEN1 (0.32) | — | |
| SCHEMBL14989970 | 0.61 | AXL (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254871-A1 | Compounds for the Treatment of Inflammation of the Central Nervous System | NEUROTEC PHARMA, S.L. (ES) | 2007-11-01 | — | — | US | claimed |
| EP-1782812-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATION OF THE CENTRAL NERVOUS SYSTEM | Neurotec Pharma, S.L. (ES) | 2007-05-09 | — | — | EP | claimed |
| EP-3545958-B1 | SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF | ESSENTIALIS INC (US) | 2024-07-10 | — | — | EP | disclosed |
| CN-107056731-B | benzothiadiazinone derivative, preparation method and application thereof | 深圳海王医药科技研究院有限公司 | 2019-12-10 | — | — | CN | disclosed |
| US-8415344-B2 | Method of treating depression | BROOKHAVEN SCIENCE ASSOCIATES, LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120129826-A1 | Method of Treating Depression | BROOKHAVEN SCIENCE ASSOCIATES, LLC (US) | 2012-05-24 | — | — | US | disclosed |
| US-8101600-B2 | Method of treating depression | BROOKHAVEN SCIENCE ASSOCIATES, LLC (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100160300-A1 | Method of Treating Depression | BROOKHAVEN SCIENCE ASSOCIATES, LLC (US) | 2010-06-24 | — | — | US | disclosed |
| EP-1663239-A4 | POTASSIUM CHANNEL MEDIATED DELIVERY OF AGENTS THROUGH THE BLOOD-BRAIN BARRIER | CEDARS SINAI MEDICAL CENTER (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20070254871-A1 | Compounds for the Treatment of Inflammation of the Central Nervous System | NEUROTEC PHARMA, S.L. (ES) | 2007-11-01 | — | — | US | disclosed |
| US-20070254871-A1 | Compounds for the Treatment of Inflammation of the Central Nervous System | NEUROTEC PHARMA, S.L. (ES) | 2007-11-01 | — | — | US | disclosed |
| US-5792764-A | ENDOCRINE DISORDERS ESPECIALLY AS A K(ATP)-CHANNEL MODULATOR | NOVO NORDISK A/S (DK) | 1998-08-11 | — | — | US | disclosed |
| WO-1997026265-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-07-24 | — | — | WO | disclosed |
| WO-1997026264-A1 | PYRIDO-1,2,4-THIADIAZINE AND PYRIDO-1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-07-24 | — | — | WO | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |
| WO-1994020460-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-09-15 | — | — | WO | disclosed |
| US-4025510-A | DYES FOR POLYESTERS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-05-24 | — | — | US | disclosed |