⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448434 | 0.72 | — | — | |
| SCHEMBL7606329 | 0.69 | NOS3 (0.30) | — | |
| SCHEMBL9730822 | 0.66 | ALOX15 (0.36) | — | |
| SCHEMBL8371992 | 0.65 | — | — | |
| SCHEMBL392669 | 0.64 | — | — | |
| SCHEMBL9940454 | 0.64 | — | — | |
| SCHEMBL1913184 | 0.64 | — | — | |
| SCHEMBL6208056 | 0.63 | TRPA1 (0.58) | — | |
| SCHEMBL8832858 | 0.63 | KDM4E (0.30) | — | |
| SCHEMBL31408049 | 0.62 | MEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246828-B1 | BENZOSULFONES WITH CALCIUM ANTAGONIST ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2005-12-07 | — | — | EP | disclosed |
| EP-1200446-B1 | OXATHIEPINO 6,5- i b /i ]DIHYDROPYRIDINES, AND RELATED COMPOSITIONS AND METHODS | ORTHO MCNEIL PHARM INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1265903-B1 | THIEPINO[3,2-B]DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | ORTHO MCNEIL PHARM INC (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-1040097-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20030225120-A1 | Dihydropyridine soft drugs, and related compositions and methods | DODD JOHN H (US) | 2003-12-04 | — | — | US | disclosed |
| EP-1192163-B1 | DITHIEPINO 6,5-b]PYRIDINES, AND RELATED COMPOSITIONS AND METHODS | ORTHO MCNEIL PHARM INC (US) | 2003-09-17 | — | — | EP | disclosed |
| EP-1296990-A2 | DIHYDROPYRIDINE COMPOUNDS FOR THE INHIBITION OF CALCIUM-INFLUX | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1265903-A1 | THIEPINO[3,2-B]DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1257554-A1 | BENZOXATHIEPINO[3,4-B]PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6476022-B1 | Oxathiepino[6,5-b]dihydropyridines, and related compositions and methods | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-11-05 | — | — | US | disclosed |
| WO-2000077009-A1 | DITHIEPINO[6,5-b]PYRIDINES, AND RELATED COMPOSITIONS AND METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-12-21 | — | — | WO | disclosed |
| CN-1034077-C | Process for preparing pyrido [2, 3-f ] [1, 4] thiazepines | ORTHO PHARMA CORP (US) | 1997-02-19 | — | — | CN | disclosed |
| EP-0462696-B1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMA CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0462696-B1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMA CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0462696-A1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462696-A1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462696-A1 | Novel pyrido [2,3-f][1,4] thiazepines and pyrido [3,2-b][1,5] benzothiazepines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-27 | — | — | EP | disclosed |
| US-5075440-A | Hypotensive, bronchodilator agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5075440-A | Hypotensive, bronchodilator agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5075440-A | Hypotensive, bronchodilator agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |