SCHEMBL3927367

SCHEMBL3927367

COCCNS(=O)(=O)N(C)CCOC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.41
LMNA P02545 5/20 0.41
HPGD P15428 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
HTT P42858 4/20 0.37
ALOX15 P16050 1/20 0.37
POLB P06746 3/20 0.36
PKM P14618 2/20 0.36
MEN1 O00255 1/20 0.36
TSHR P16473 1/20 0.36
KMT2A Q03164 1/20 0.36
GSTO1 P78417 1/20 0.35
CASP3 P42574 1/20 0.33
USP2 O75604 1/20 0.33
PIK3CD O00329 1/20 0.32
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22912535 0.84 ALDH1A1 (0.41) ALDH1A1LMNAHPGDSMN1; SMN2KDM4E
SCHEMBL18312520 0.81 ALDH1A1 (0.56) ALDH1A1LMNAHPGDSMN1; SMN2KDM4E
SCHEMBL22912534 0.76 ALDH1A1 (0.41) ALDH1A1LMNAHPGDSMN1; SMN2KDM4E
SCHEMBL22912557 0.73 ALDH1A1 (0.42) ALDH1A1LMNAHPGDSMN1; SMN2KDM4E
SCHEMBL3195491 0.73 LIPG (0.39) ALDH1A1MEN1KMT2AGSTO1CASP3
SCHEMBL1769499 0.72 GFPT1 (0.37) GSTO1
SCHEMBL10090160 0.72 MEN1 (0.43) MEN1TSHRKMT2AGSTO1CASP3
SCHEMBL29153560 0.72
SCHEMBL17327626 0.71 ALDH1A1 (0.48) ALDH1A1LMNAHPGDSMN1; SMN2KDM4E
SCHEMBL3049834 0.70 PIK3CD (0.37) GSTO1CASP3PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1797078-A4 COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III ASTRAZENECA AB (SE) 2009-04-01 EP claimed
EP-1797078-A1 COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III AstraZeneca AB (SE) 2007-06-20 EP claimed
WO-2006033630-A1 COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III ASTRAZENECA AB (SE) 2006-03-30 WO claimed
EP-1797078-A4 COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III ASTRAZENECA AB (SE) 2009-04-01 EP disclosed
EP-1797078-A1 COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III AstraZeneca AB (SE) 2007-06-20 EP disclosed
WO-2006033630-A1 COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III ASTRAZENECA AB (SE) 2006-03-30 WO disclosed