Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12526399 | 0.87 | CYP2C19 (0.50) | MAPTKDM4EALDH1A1TDP1RAB9A | |
| SCHEMBL4187236 | 0.84 | MAPT (0.51) | MAPTKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL3936383 | 0.81 | CYP1A2 (0.43) | MAPTALDH1A1SMN1; SMN2KMT2ACYP2C19 | |
| SCHEMBL29966397 | 0.81 | ADRA2A (0.48) | MAPTALDH1A1SMN1; SMN2KMT2ACYP2C19 | |
| SCHEMBL12526403 | 0.81 | ADRA2A (0.48) | MAPTALDH1A1SMN1; SMN2KMT2ACYP2C19 | |
| SCHEMBL6745383 | 0.80 | CYP2C19 (0.46) | MAPTKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL17028594 | 0.80 | CYSLTR2 (0.45) | KDM4EALDH1A1SMN1; SMN2KMT2AGLA | |
| SCHEMBL7188600 | 0.80 | MAPT (0.55) | MAPTKDM4EALDH1A1TDP1MAPK1 | |
| SCHEMBL3135029 | 0.79 | L3MBTL1 (0.55) | MAPTKDM4EALDH1A1TDP1RAB9A | |
| SCHEMBL13555429 | 0.79 | MAPT (0.49) | MAPTRAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |