Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 17/20 | 0.64 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925573 | 0.90 | FAAH (0.65) | FAAHSMN1; SMN2NLRP3KDM4EMAPT | |
| SCHEMBL3928766 | 0.88 | PTGDR2 (0.55) | FAAHPTGDR2KDM4E | |
| SCHEMBL3928637 | 0.87 | PTGDR2 (0.59) | PTGDR2KDM4E | |
| SCHEMBL3927273 | 0.86 | CCR5 (0.57) | PTGDR2 | |
| SCHEMBL3928880 | 0.86 | PTGDR2 (0.72) | PTGDR2SMN1; SMN2KDM4E | |
| SCHEMBL3927267 | 0.86 | PTGDR2 (0.56) | PTGDR2SMN1; SMN2KDM4E | |
| SCHEMBL3933237 | 0.85 | CCR5 (0.56) | PTGDR2 | |
| SCHEMBL3928937 | 0.85 | PTGDR2 (0.57) | PTGDR2 | |
| SCHEMBL3938436 | 0.85 | CCR5 (0.54) | PTGDR2KDM4E | |
| SCHEMBL3927527 | 0.84 | FAAH (0.55) | FAAHKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | claimed |
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |