Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1415100 | 1.00 | TSHR (0.47) | TSHRCA1CA2LMNAFKBP1A | |
| SCHEMBL5549483 | 0.88 | ALDH1A1 (0.44) | FKBP1AMAPTCTSCHPGDALDH1A1 | |
| SCHEMBL5461273 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL6871388 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL13314011 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL14605828 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL9169159 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL2178522 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL14117906 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 | |
| SCHEMBL9733234 | 0.86 | TSHR (0.56) | TSHRFKBP1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866327-A1 | IMPROVED PROCESS FOR PREPARATION OF HIGHLY PURE TRANDOLAPRIL | Lupin Ltd. (IN) | 2007-12-19 | — | — | EP | claimed |
| WO-2006085332-A1 | IMPROVED PROCESS FOR PREPARATION OF HIGHLY PURE TRANDOLAPRIL | LUPIN LIMITED (IN) | 2006-08-17 | — | — | WO | claimed |
| EP-2906536-A1 | AN IMPROVED PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | Piramal Enterprises Limited (IN) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014057404-A1 | AN IMPROVED PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE | Piramal Enterprises Limited (IN) | 2014-04-17 | — | — | WO | disclosed |
| EP-2044010-A1 | NEW PHARMACEUTICAL INTERMEDIATES IN THE SYNTHESIS OF ACE- INHIBITORS AND THE USE THEREOF | EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság (HU) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007132277-A1 | NEW PHARMACEUTICAL INTERMEDIATES IN THE SYNTHESIS OF ACE- INHIBITORS AND THE USE THEREOF | EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság (HU) | 2007-11-22 | — | — | WO | disclosed |
| EP-1675827-A1 | NOVEL METHOD FOR PREPARATION OF CRYSTALLINE PERINDOPRIL ERBUMINE | Lupin Limited (IN) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037788-A1 | NOVEL METHOD FOR PREPARATION OF CRYSTALLINE PERINDOPRIL ERBUMINE | LUPIN LTD. (IN) | 2005-04-28 | — | — | WO | disclosed |
| US-5401766-A | Hypotensive agents with vasodilation | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5162362-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | disclosed |
| US-5158959-A | Treatment of hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-27 | — | — | US | disclosed |